Level 95 Poisonous Concoction Pathfinder^3.16

Notes

> PLAYSTYLE <
While clearing you only really use Poisonous Concoction to kill rares and to charge your Plague Bearer. For the rest it's just shield charging around with Plague Bearer active.

For bossing you try to use Focus whenever you have an opportunity to throw a lot of flasks for a few seconds. We also spam withering step as long as we're in range of the boss to apply wither stacks.
Make sure your despair curse stays up, and if possible your ancestral protector too(we use it only for the buff, it doesn't have to hit the boss).

In general you should have enough charge generation on your life flask to just press it if we stand in a degen.

> VARIATIONS <
THESE VARIATIONS CAN HAVE DIFFERENT ASCENDANCY POINTS, DON'T FORGET TO RESPEC THEM

Before rolled flasks: Before you have rolled flasks Iron Reflexes is not  that great. Replace your Jade Flask with a Granite and make sure to get some energy shield(10% of life gained as es craft on chest is great) since we use Ghost Dance here
Endgame - No Cluster: not having a cluster is not great on Poisonous Conoction, but this is probably the tree you want before you have it.
Endgame - Cluster: this is the endgame setup you want to work towards

> LEVELING <
Leveling is super smooth. Before level 12 we use Caustic Arrow for clear and Puncture for single target(mainly for Brutus, just keep him bleeding and kite him in circles).
Once we hit level 12 we can switch to Poisonous Concoction. You link it to Volley and Lesser Multiple Projectiles(replace LMP with Void Manip if you don't have the transmutes).
Early on we take the "Poison you inflict to non-poisoned enemies deals 300% increased damage" mastery to help with your damage, later on this is not worth it anymore though since it only applies to one of your concoctions(and you throw 9).
From there on out just follow the guide, once you have 100% chance to poison in town(so without Herald of Agony) you can drop Herald of Agony and start to run Grace.

> FLASK SETUP <
The main idea of this build is to roll "charges gained when hit" on every utility flask, and then use instilling orbs or the crafting bench(recipe is in the Epilogue!) to get "Used when charges reach full" on every flask.
These flasks then trigger Pathfinder's "Master Surgeon" node which gives you 6% life whenever a flask is used. This is all fully automatic and means you'll never have to press any utility flask.

In the endgame we have 115% increased charges gained, this means we gain 15 charges when hit with the flagellant mod, and 2 charges per second from Nature's Boon.
Most of our flasks use 18 or 27 charges, so all of those get used when taking just 2 hits(and potentially less if you kill stuff in the meanwhile or Nature's Boon triggers).

Your Sulphur, Jade, Quicksilver and Life Flask are pretty mandatory. Your last flask however you can swap out for any flask you want:
- Silver flask for max dps on bosses
- Ruby flask for bosses that deal fire damage(the Exarch perhaps??)
- Sapphire flask for bosses that deal cold damage(Shaper/Elder/Maven)
- Basalt flask for maximum armour
- Amethyst for chaos res
- Feel free to experiment! As long as you can roll Flagellant(7 charges gained when hit) on it it's all good!

> I DON'T HAVE ALL THE FLASKS ROLLED YET <
If you don't have rolled flasks yet I wouldn't recommend speccing into Iron Reflexes yet. I included a tree specifically for when you don't have the flasks rolled yet.
Before we have all flasks rolled I recommend running a Granite flask instead of the Jade flask so your Molten Shell is a bit stronger.
Once you have at least 3 utility flasks rolled with 4 or 5 charges gained when hit and "Used when charges reach full" on all of them you can switch to one of the endgame setups.

> WHY NOT MASTER TOXICIST? CAN I TAKE IT ANYWAY? <
Short answer: yes, feel free to take it instead of Nature's Boon.
Long answer:
The most realistic way for this build to die is if you don't get hit for a while and get hit by something with your flasks down. Nature's Boon makes your flask uptime near-permanent even without getting hit.
Now we need to drop SOMETHING to grab this. You can't drop Nature's Reprisal because the AoE is too important, and you can't drop Master Surgeon because that's the entire build.
Master Toxicist is the only option left, since the prolif only applies your strongest poison that part isn't that strong, so we're basically dropping 20% more damage for real flask uptime.

> GEARING <
Jewels: reforge chaos from Harvest is your friend here!

Most other gear is pretty simple so I'll dedicate this section to some gearing you can do to go beyond what's in this PoB:
- Awakened Gems are really good on this build. Awakened GMP gives you an extra projectile, and Awakened Void Manipulation gives you an extra level(and might be relatively easy to get)
- Anomalous Withering Step gives you 2 extra wither stacks per cast of Withering Step.
- You could get a +2 amulet or an amulet with +1 and Damage Over Time Multiplier.

> ENCHANTS <
- 40% Poisonous Concoction Damage
- 24% Poisonous Concoction AoE (for easier overlaps)
- Withering Step applies 3 additional debuffs
- Plague Bearer +5% to max plague value

> COMMON MISTAKES <
- Not getting 100% chance to poison(use a jewel to get the last 5% if needed, or take it on the tree)
- Not having enough accuracy
- Having an instant life flask instead of "increased charges used"
- Forgetting you need an itemlevel 80 flask to roll the "Flagellant" mod(7 charges gained when hit)
- Accidentally equipping a weapon(disable autoequip)
- No really, disable autoequip
- You will accidentally equip a weapon, disable autoequip
- Ok, you can also equip a disabled weapon in your main hand using stat requirement snapshotting(as explained in the video)